I D
× COMMENTARYEDITOR'S PAGECOVER STORYIN THE NEWSNEWSFRONTSCHEMENTATOR + Show More
Chemical EngineeringChementator briefs
NITROGEN UTILIZATION Late March, the first nitrogen fertilizer produced from…
BUSINESS NEWSTECHNICAL & PRACTICALTOWER DOCTORFEATURE REPORTFACTS AT YOUR FINGERTIPSEQUIPMENT & SERVICESFOCUSNEW PRODUCTS + Show More SHOW PREVIEWS

Comment Processing & Handling

Phosphine-based ligand now available on the kilogram scale

By Gerald Ondrey |

Sinocompound Catalysts Co., Ltd. (Zhangjiagang, China; en.sinocompound.com) says it is now producing the phosphine-based QPhos ligand in kilogram quantities for commercial use. With this ligand now accessible on a large scale, scientists across the globe can incorporate QPhos-based catalysts into their drug discovery, screening and process-development programs to optimize and streamline product development. QPhos is a promising ligand in metal-catalyzed cross-coupling reactions, which are fundamental to building carbon-carbon bonds featured in most drug scaffolds. However, until now QPhos has not been readily available in commercial quantities, hindering its adoption in process development and scale-up programs, says the company. QPhos is a robust dialkylarylphosphine ligand (diagram) first developed by John Hartwig, the Henry Rapoport Professor of Chemistry at the University of California, Berkeley (hartwig.cchem.berkeley.edu) for metal-catalyzed cross-coupling reactions, and reported in a 2002 article published in J. Org. Chem. Bulky and electron-rich, QPhos performs “excellently” in many transformations, including α-arylation of carbonyl compounds and late-stage C–C bond formation, says the company. “There’s an enormous…
Related Content

Chemical Engineering publishes FREE eletters that bring our original content to our readers in an easily accessible email format about once a week.
Subscribe Now
Solve turbomachinery problems: Miba Tilting Pad Bearings
Six Steps to Designing a Storage Vessel That Really Works
SICK Solutions for Cleaner Industries - Powerful Transitions
Gain a Digital Line of Sight Across the Whole Lifecycle of the Plant with a Digital Twin
Granulating High Viscous Melts in the Food Industry

View More