Advances improve membrane chromatography performance
Sartorius Stedim Biotech
The Sartobind membrane chromatography adsorber capsules have recently been redesigned to improve binding capacities, reduce void volumes, reduce buffer consumption and lower operating costs. These membrane chromatography capsules are used to recover large-molecular-weight proteins, such as blood factors and conjugated proteins, viruses and virus-like particles. Several capsule sizes, with a 4-mm bed height, are now available, from a 1-mL nano unit up to the newer 2.5-L version. The capsules’ upstream flow channels have been optimized and an internal core forms a miniaturized downstream channel. Unlike traditional membrane adsorbers, the Sartobind membrane capsules take into account specific chromatographic process parameters, such as back-mixing effects and elution volumes, providing substantial performance advantages, says the company. — Sartorius Stedim Biotech, Göettingen, Germany