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Facts at your Fingertips: Clean-in-Place (CIP) Systems

By Scott Jenkins, Chemical Engineering magazine |

Cleaning equipment surfaces is critical for processes involving biological materials to prevent microbial contamination. Clean-in-place (CIP) systems play a key role. In addition to preventing contamination, CIP systems also remove grit, scale and organic matter, which may affect process performance. This one-page reference provides information on CIP system equipment and operating considerations for bioprocessing facilities. CIP equipment CIP systems supply fluid to a spray device inside the vessel, which sprays the solution onto the vessel walls. A variety of spray devices are available, including static sprayballs and fluid-driven orbital cleaners. Sprayballs are high-flow, low-pressure devices often used to clean tanks smaller than 15-ft dia., while fluid-driven orbital cleaners are low-flow, high-pressure devices used for tanks greater than 15-ft dia. Tanks. Tanks are typically constructed from 304L or 316L stainless steel. Internal welds should be ground smooth and dead spots should be minimized. Internal polishing of CIP vessels is usually not required. Detergent tanks should be equipped with agitators to ease the preparation of detergent solutions. Pumps. There will likely be multiple unit operations and tanks using the…
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