I D
× COMMENTARYCOVER STORYIN THE NEWSNEWSFRONTSCHEMENTATOR + Show More
Chemical EngineeringChemenator Briefs
Cellulosic ethanol Clariant AG (Muttenz, Switzerland; www.clariant.com) has produced the…
TECHNICAL & PRACTICALTOWER DOCTORFEATURE REPORTFACTS AT YOUR FINGERTIPSSOLIDS PROCESSINGEQUIPMENT & SERVICESAPPLIED TECHNOLOGIESFOCUS
Focus on Pumps
Track pump operation with this monitoring system This company has…
SHOW PREVIEWS

Comment PDF Business & Economics

A Bit of Extra Lab Effort Can Prevent Grief During Scaleup

By Francis X. McConville, Impact Technology Consultants |

    It’s an old saw, but I’ve long held that process development is very much a team effort. Developing safe, robust and scaleable chemical processes calls for close collaboration between synthesis chemists, process development engineers and pilot plant personnel. But experience shows that, particularly in many fine chemical and pharmaceutical organizations, researchers fail to put this principle into practice until it’s too late. Finding out in the process Hazop that the environmental permits prohibit the use of your chosen extraction solvent in your company’s pilot plant is no laughing matter. Nor is arriving at the contract manufacturer’s site for the project only to learn that the designated equipment is not set up for vacuum distillation (it happened to me!). Attention to just such mundane details is, unfortunately, still an important part of process technology transfer and scaleup. Clearly, good communication is the key ingredient to minimizing such painful experiences. However, the more glamorous role of process development, at least on paper, is the collection of quantitative data on process performance to help streamline the scaleup effort. This is where experienced engineers and their…
Related Content
Business News: July 2022
Plant Watch Solvay completes PVDF capacity expansion in Changshu June 13, 2022 — Solvay S.A. (Brussels, Belgium; www.solvay.com) has significantly…

Chemical Engineering publishes FREE eletters that bring our original content to our readers in an easily accessible email format about once a week.
Subscribe Now
GMP In The Cosmetic Industry
Solve turbomachinery problems: Miba Tilting Pad Bearings
Six Steps to Designing a Storage Vessel That Really Works
SICK Solutions for Cleaner Industries - Powerful Transitions
Gain a Digital Line of Sight Across the Whole Lifecycle of the Plant with a Digital Twin

View More